1. Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation
Pr. Roquilly and colleagues are publishing an article in Intensive Care Medecine journal. In this publication, they were able to identify two robust clinical subphenotypes by extensively analyzing HAP data sets. Their associations with respiratory microbiome composition, systemic inflammation, and treatment efficacy in independent data sets highlight their potential for prognostic value and predictive enrichment in future clinical trials aimed at personalized therapies.
https://doi.org/10.1007/s00134-025-07884-3
2. Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
Pr. Josset and colleagues are publishing an article in Cell Reports Medicine journal. In this work, they revealed the composition of the lung virome in critically ill patients and suggested a potential role of the virome in the pathophysiology of HAP.
